Acetyl-L-carnitine and Alpha Lipoic Acid Improved Learning
July 31, 2007 Dogs between ages seven and almost nine years were given supplements of alpha lipoic acid and acetyl-L carnitine twice daily over approximately two months. The animals given the supplements were noted to have significantly fewer errors in reaching learning criteria on two or more discrimination tasks compared to controlled administered placebo. Authors indicated the long term supplementation of alpha lipoic acid and acetyl-L carnitine may be effective in attenuating age-associated poor cognitive health by slowing the rate of mitochondrial decay and cellular aging.
In an animal study published July 2007 in the journal FASEB. The authors suggest that long-term maintenance on acetyl-L carnitine and alpha lipoic acid may be effective in attenuating age-associated cognitive decline by slowing the rate of mitochondrial decay and cellular aging.
Beagle dogs between 7.6 and 8.8 years of age administered a twice daily supplement of {alpha}-lipoic acid (LA) and acetyl-L-carnitine (ALC) over ~2 months made significantly fewer errors in reaching the learning criterion on two landmark discrimination tasks compared to controls administered a methylcellulose placebo. Testing started after a 5 day washin. The dogs were also tested on a variable delay version of a previously acquired spatial memory task; results were not significant. The improved performance on the landmark task of dogs supplemented with LA + ALC provides evidence of the effectiveness of this supplement in improving discrimination and allocentric spatial learning.
We suggest that long-term maintenance on LA and ALC may be effective in attenuating age-associated cognitive decline by slowing the rate of mitochondrial decay and cellular aging.--Milgram, N. W., Araujo, J. A., Hagen, T. M., Treadwell, B. V., Ames, B. N. Acetyl-L-carnitine and {alpha}-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests.
Milgram NW, Araujo JA, Hagen TM, Treadwell BV, Ames BN. Acetyl-L-carnitine and {alpha}-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests. FASEB J. 2007 Jul 10;
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