Efficacy of Nattokinase in treating and preventing heart disease and stroke
Natto from fermented soybeans is enlivened by the activity of Bacillus subitilis, contains a potent fibrinolytic enzyme, called nattokinase produced from the dried culture filtrate of partially distilled a profibrinolytic serine proteinase derived Bacillus subtilis. Nattokinase is a pro-fibrinolytic (clot dissolving) enzyme that helps to promote healthy circulation of the blood by breaking up cross linked fibrin and soluble fibrin monomers that may contribute to high blood pressure and other cardiovascular conditions. •
Used in the prevention and treatment of the following: angina pectoris, cardiac arrest, stroke, high blood pressure, hypertension, diabetes from pancreatic dysfunction, arterial embolism, varicose veins.
Nattokinase is an enzyme found in the Japanese food natto (extracted from natto cheese)– that is increasing in popularity in the US as a supplement used by sufferers of high blood pressure and other cardiovascular conditions, should soon be available as a functional food with new clinical research behind it.
Nattokinase is a naturally-occurring profibrinolytic enzyme that helps dissolve unhealthy coagulation of blood and supports fibrinolytic activity. Nattokinase is a particularly potent treatment because it enhances the body’s natural ability to fight blood clots in several different ways and has many benefits including convenience of oral administration, confirmed efficacy, prolonged effects, cost effectiveness, and can be used preventatively. It is a naturally occurring, food dietary supplement that has demonstrated stability in the gastro-intestinal tract.
The properties of nattokinase closely resemble those properties of plasmin so it dissolves fibrin directly! It enhances the body’s production of both plasmin and other clot-dissolving agents, including urokinase (endogenous). Nattokinase may actually be superior to conventional clot-dissolving drugs such as recombinant tissue plasminogen activators (rt-PA), urokinase, and streptokinase, which are only effective therapeutically when taken intravenously within 12 hours of a stroke or heart attack. Nattokinase, however, may help prevent the conditions leading to blood clots with an oral daily dose of as little as 2,000 fibrin units (FU) or 50 grams of natto.
Nattokinase appears to have the added benefit of significantly reducing elevated blood pressure (an often concomitant condition in cardiovascular disease risk factors, such as high fibrin). Nattokinase appears to be safe, and has been used for over 1,000 years safely with no reports of toxicity. Before taking Nattokinase, however, because of its action, it is recommended that you consult with your healthcare professional or pharmacist to see if Nattokinase is for you. Various other nutritional supplements / herbs have been reported to have fibronlytic activity, however, the potency of Nattokinase appears to be superior.
Nattokinase appears to be an activator of various other metabolic enzymes and vitamins, cleaving them from their inactive to their active forms. The strength and magnitude of this direct support for the metabolic enzymes of the body, from an oral enzyme supplement, is unique to Nattokinase and shows great promise as a nutritional supportive agent in exciting and diverse ways.
Nattokinase is a systemic enzyme that
Supports the fibrinolytic blood clearing system (breakdown of fibrin
protein in the blood)
Promotes cardiovascular health
Every tissue in your body relies on your heart to circulate blood through approximately 60,000 miles
of blood vessels. Enzymes, which accelerate chemical reactions, can
help with a lot more than just digestion. Systemic enzymes are a
special class of enzymes that work on every system in your body to support
health. Nattokinase, a systemic enzyme derived from the fermented
soy food natto, supports good circulation and thus cardiovascular health.
thousands of chemical reactions in your body. Systemic enzymes are a
special enzyme class that work on every system in your body to support
your complete -- or systemic -- health.
enzymes, such as papain, bromelain, pancreatin and nattokinase, each work
in different ways. The results can include reducing cellular
irritation, promoting clear blood flow and supporting balanced immune
reactions for your short-term comfort and long-term health.
Healthy circulation occurs
when your blood flows smoothly. It takes complex cascades of events
to maintain this cardiovascular balance. Nattokinase doesn't inhibit
blood clot formation. Instead, it works to support healthy
circulation three ways.
First, Nattokinase assists
the fibrinolytic blood clearing system by breaking down cross-linked
fibrin protein deposits in the blood. Second, in preliminary
studies, natto extracts promote clear blood flow by reducing Euglobulin
Lysis Time (ELT). Third, nattokinase supports blood clearing by breaking
down Plasminogen Activator Inhibitor-1 (PAI-1), an inhibitor of an enzyme
that helps keep blood flowing. Lifestyle conditions such as high
stress, high glucose levels and high amounts of adipose tissue are
associated with increased PAI-1 levels.
Healthy circulation can do
wonders to support your total health. When your circulation isn't
balanced, then your tissues aren't getting enough nutrients and your blood
isn't clearing enough wastes away, which can increase cellular irritation
and decrease overall cell health. Alternately, systemic enzymes such
as nattokinase support healthy circulation so your tissues can get optimal
levels of nutrients delivered and wastes removed for your better health.
History: Hiroyuki Sumi, MD, a researcher of the Japan Ministry of Education is the scientist who discovered the enzyme and its benefits while searching for a natural way to break down excess fibrin in the blood.
The legend about the discovery of natto began thousands of years ago with Yoshiie Minamoro, a
famous Japanese warrior, who was forced to pack hot cooked soybeans in
straw for traveling. When the soybeans were later unpacked, the
sticky mess was considered spoiled. But when the horses, notoriously
picky eaters, preferred this soy food, then people began consuming natto
and discovering its health benefits.
Technicals: GRAS approval from the FDA.
Vitamin B2 and K2, and various functional enzyme such as nattokinase are produced owing to the working of Bacillus subtilis Natto. testing
Sources: Bacillus subtilis
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