An important physiological agent synthesized by the body.
A natural metabolite of the amino acid methionine. It is the precursor for three fundamental biochemical pathways. Involved in over 40 biochemical reactions in the body. It is a co-factor in many critical biochemical reactions. It is found in every living organism. Essential to the manufacture of important brain compounds such as neurotransmitters and phospholipids. It improves the binding of neurotransmitters to receptor sites, causing increased serotonin and dopamine activity and improved brain cell membrane fluidity, resulting in significant improvement.
It can increased levels of serotonin, dopamine, and phosphatidylserine, which can enhance mood and emotional well being.
In Studies: One study on it and melatonin published in the Journal of Neurochemistry in 1995. Demonstrated the perfect orchestration that occurs between levels of it and melatonin. The "nyctohemeral" rhythm (pertains to both day and night) was documented. Sitaram BR, Sitaram M, Traut M and CB Chapman. 1995. Neurochem 65: 1887-1894
Technicals: SAMe is an active lipotrope form of Methionine.SAMe is manufactured within
the body but it is also made synthetically. SAMe is a cofactor in a number of
critical biochemical reactions and is found in almost every tissue of the body. SAMe has been used in clinical studies to treat depression, schizophrenia, demyelination diseases, liver disease, dementia, arthritis, peripheral neuropthy and other conditions.
SAMe alleviates all forms of depression. Several studies have confirmed
that SAMe is up to15% more effective in the treatment of depression than traditional pharmaceutical anti-depressants.
SAMe improves and normalizes liver function. SAMe is used in Europe in the
treatment of cirrhosis and damage caused by alcohol. SAMe is essential for the
production of glutathione, a powerful antioxidant that protects the body from the damaging effects of free radicals.
SAMe reduces the number of trigger points, reduces fatigue, reduces morning
stiffness,and improves mood in fibromyalgia patients.
SAMe improves the binding of neurotransmitters to their receptors sites in the brain. SAMe is essential for the regeneration of neuron axons following injury. SAMe is also essential for the formation of myelin sheaths that surround axons.
In tests SAMe has shown great promise in the treatment of Peripheral Neuropathy,and HIV related peripheral Neuropathy. Alzheimerís and Parkinsonís patients have very low levels of SAMe.
SAMe is currently under investigation as a treatment for Parkinsonís disease.
SAMe is used during detoxification of drug dependent patients to counteract anxiety and depression.
SAMe has shown great promise in the treatment of Peripheral Neuropathy and HIV related peripheral Neuropathy.
The statements on this Web site have not been evaluated by the Food and Drug Administration (FDA). And are not intended to diagnose, treat, cure or prevent disease. The information presented is not intended to replace medical advice or treatment from your own doctor or healthcare provider. Nothing presented here is intended as a substitute for prescription medication or any other medical treatment prescribed by your doctor.