An amino acid thought to increase stamina and therefore fight fatigue.
Non-Essential - Proteogenic - Glycogenic - Acid Side Chain
Aspartic Acid is a non essential amino acid that may be interconvertible with the amino acid Asparagine. Asparatic acid is synthesized from glutamate. Asparatic acid aids in the expulsion of ammonia via the urea cycle, thus increasing the resistance to fa Aspartic Acid aids in the expulsion of harmful ammonia from the body. When ammonia enters the circulatory system Aspartic Acid acts as a highly toxic substance which can be harmful to the central nervous system. Recent studies have shown that Aspartic Acid may increase resistance to fatigue and increase endurance.
Aspartic Acid assists in detoxification of ammonia and as a result provides protection to the liver. Aspartic Acid promotes uptake of other toxins from the bloodstream and trace elements in the gut. Aspartic Acid also connects the nitrogen and carbohydrate metabolism which is responsible for a large part of the energy cycle in the body. Aspartic Acid assists in the transport of magnesium and potassium to cells.
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Main Functions:
Aspartic Acid is interconvertible with Asparagine, and these two amino acids have many functions in common.
Increases stamina.
One of the two main excitatory amino acids, the other being Glutamate (Glutamic Acid).
Helps protect the liver by aiding the removal of ammonia.
Involved in DNA and RNA metabolism.
Involved in immune system function by enhancing immunoglobulin production and anti- body formation.
Asparatic acid is a natural dibasic amino acid, involved in transamination reactions, the ornithine cycle, and the formation of carnosine, anserine, purines, and pyrimidines.
1. Has a protective function over the liver.
2. Helps in detoxification of ammonia.
3. Promotes mineral uptake in the intestinal tract.
Increases resistance to fatigue
Involved in the formation of RNA and DNA, the chemical bases of heredity and carriers of genetic information
Salts of aspartic acid increase stamina and endurance
Protects the liver and promotes normal cell function
Builds up the immune system, producing immunoglobulins and antibodies
History: First isolated in 1868 from legumin in plant seed.
Technicals: Aspartic Acid is used as dietetic supplement, additive for kinds of soft drink. In medicine, it is used as ammoniac detoxicating agent. hepar function accelerator and fatigue refresher. Aspartic acid is one of two acidic amino acids. Aspartic acid and glutamic acid play important roles as general acids in enzyme active centers, as well as in maintaining the solubility and ionic character of proteins. Proteins in the serum are critical to maintaining the pH balance in the body; it is largely the charged amino acids that are involved in the buffering properties of proteins. Aspartic acid is alanine with one of the β hydrogens replaced by a carboxylic acid group. The pKa of the β carboxyl group of aspartic acid in a polypeptide is about 4.0. Note that aspartic acid has an α-keto homolog, oxaloacetate, just as pyruvate is the α-keto homolog of alanine. Aspartic acid and oxaloacetate are interconvertable by a simple transamination reaction, just as alanine and pyruvate are interconvertible.
Aspartic Acid is one of two amino acids (the other is glutamic acid) that has a negatively charged carboxylate group on the side chain. This gives Aspartic Acid an overall negative charge at physiological hydrogen ion concentrations (approximately pH 7.3). Although Aspartic Acid is considered a non-essential amino acid, it plays a paramount role in metabolism during construction of other amino acids and biochemicals in the citric acid cycle. Among the biochemicals that are synthesized from Aspartic Acid are asparagine, arginine, lysine, methionine, threonine, isoleucine, and several nucleotides.
Sources: Aspartic Acid is found in abundance in plant proteins, especially in sprouting seeds but can be manufactured in the body from oxaloacetic acid. Found in dairy, beef, poultry, sprouting seeds
Synergist: Aspartic Acid is synergistic with Vitamin B6, zinc, magnesium and potassium.
Signs or Symptoms of a Deficiency: Calcium and magnesium deficiencies. Because of this, low aspartic acid levels should lead the health care professional to test for calcium and/or magnesium deficiencies.
Excess maybe seen in: Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease), Epilepsy, especially right after a seizure, Stroke
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