Involved with the important brain neuro-transmitters epinephrine, norepinephrine and dopamine. Tyrosine is synthesized in the body from existing levels of phenylalanine. Stress is associated with reduced levels of norepinephrine. Tyrosine prevents reduction of norepinephrine levels that are associated with stress. Many clinical studies, along with a large body of anecdotal evidence, indicate that tyrosine may prove to be a vital substance in alleviating depression, as well as the irritating symptoms of premenstral syndrome. Tyrosine is used as an aid in the treatment of and withdrawal from cocaine addiction. Tyrosine is a direct precursor to Thyroxine as well as being a precursor to Adrenaline and Noradrenaline. Thyroxine is a primary Thyroid hormone. Thyroxine deficiency results in a series of conditions including excess weight gain, cold hands and feet, decreased basal metabolism, etc.
Precursor to norepinephrine and dopamine
Non-essential amino acid (PA is converted into it first)
Studied as an effective aid to cocaine withdrawal •
When Tyrosine enters the brain, it is engaged by vitamins and minerals. This process metamorphosizes tyrosine into norepinephrine and dopamine. These two chemicals aid in the release of stored body fat, regulate metabolism and control appetite. They stimulate your sex drive, immune system and pituitary to release Growth Hormone. Tyrosine transmits nerve impulses to the brain; helps overcome depression; Improves memory; increases mental alertness; promotes the healthy functioning of the thyroid, adrenal and pituitary glands. Can assist a sluggish thyroid and aid the dieter in losing excess, unwanted pounds. It is an excellent stimulant free energy booster and fat burner.
Tyrosine helps to form red and white blood cells and enhance the immune function. Known to suppress the appetite; and may aid in loosing excess weight. This amino acid may stimulates growth hormone release for positive muscle growth and the burning off of excess fat. L-Tyrosine helps break down Phenylalanine. A lack of L-Tyrosine triggers a deficiency of the hormone norphinephrine resulting in depression and mood disorders. Is used to synthesize epinephrine and dopamine. Tyrosine acts against depression by releasing catecholamine, an organic compound that stimulates nerve cells in the brain to produce epinephrine and norepinephrine. Dopamine is released with L-Tyrosine and transmits nerve impulses throughout the brain and is believed to produce a calming effect in depressed patients.
It is a direct precursor to Thyroxine, a primary thyroid hormone, as well as Adrenaline and Nor-adrenaline. Thyroxine has been found to increase metabolic rate and control growth rate.
L-Tyrosine is a necessary amino acid in the production of neurotransmitters including epinephrine, norepinephrine, and dopamine. L-Tyrosine also appears to have a mild stimulatory effect on the central nervous system.
Plays a big part in human energy levels.
Only the l -stereoisomer appears in mammalian protein. It is a precursor of the adrenal hormones epinephrine and norepinephrine as well as of the thyroid hormones, including thyroxine. Melanin, the skin and hair pigment, is derived from this amino acid. Tyrosine residues in enzymes have frequently been shown to be associated with active sites. Modification of these residues with various chemicals often results in a change in the specificity of the enzyme toward its substrates or even in total destruction of its activity.
Precursor to neurotransmitters dopamine, norepinephrine, epinephrine (adrenaline) and melanin.
Effective anti-depressant for norepinephrine-deficient depressions. It is preferred over Phenylalanine, which is also a precursor to all of these neurotransmitters. Phenylalanine is one step removed from the metabolic process, and can aggravate high blood pressure.
Precursor to thyroxine and growth hormone.
Increases energy, improves mental clarity and concentration.
Requires pyridoxal-5-phosphate (P5P) a form of vitamin B6 to be converted into norepinephrine. P5P deficiency will lower norepinephrine levels, even if Tyrosine levels are normal.
In Studies: Dr. Alan J. Gelenberg of Harvard Medical School reported in the American Journal of Psychiatry that L-Tyrosine can be effective in treating depression. Dr. Gelenberg reported that patients had a positive response to L-Tyrosine. Three out of five patients in another study by Dr. Gelenberg showed reductions in depression by at least 50% after receiving L-Tyrosine supplementation for a period of four weeks. Control patients receiving placebo showed reductions in only one of four.
A study by Dr. I. Goldberg in Lancet revealed that catecholamine also controls immune system output. Allergy sufferers have responded well to Tyrosine. In the American Journal of Psychiatry, Dr. Alan J. Gelenberg postulated that a lack of available tyrosine results in a deficiency of nor adrenaline at a specific brain location, which in turn relates to mood problems such as depression.
In a study, tryptophan and tyrosine were used in conjunction with the anti-depressant imipramine to treat chronic cocaine abuse with a reported 75-80 percent
success rate. Researchers at UCLA have also reported favorably on regimens
containing tryptophan and tyrosine for the treatment of cocaine abuse.
In Science magazine it was reported that Tyrosine lowers blood
pressure by increasing Norepinephrine metabolites which through feedback shut down
sympathetic output. In this same issue it was found that Tyrosine increased blood pressure
38% to 49% in hypotensive rats through accelerated peripheral synthesis of catecholamine.
Dr. Earl Mindell, stated that Tyrosine showed amazing results in tests on patients who suffered from severe mentaland emotional depression.
History: In 1846 tyrosine was obtained as a product of the degradation of the protein casein (from cheese). Tyrosine was synthesized in the laboratory in 1883, and its structure was thus determined.
Technicals: Tyrosine can be synthesized in the body from phenylalanine.
Synergist: The conversion step from L-tyrosine to norepinephrine may be enhanced by the cofactors vitamins B6 and vitamin C.
Signs or Symptoms of a Deficiency: Depression, Chronic Fatigue Syndrome, Gulf War Syndrome, Hypothyroidism, Parkinson's Disease, Drug addiction and dependence.
A Tyrosine deficiency caused Thyroxine deficiency results in a series of conditions including excess weight gain, cold hands and feet, and decreased basal metabolism.
Excess maybe seen in: Hypertthyroidism
Chronic liver disease; cirrhosis
Caution: When the enzyme that catalyzes the transformation of phenylalanine to tyrosine is not active because of a hereditary defect, the serious disease known as phenylketonuria (PKU) results. Other defects in tyrosine metabolism include the rare hereditary disorder known as alkaptonuria, characterized by discharge of a urine which darkens on standing exposed to air.
Warning: Do not use L-phenylalanine or L-tyrosine if you are using MAO inhibitors for
depression (it can cause an elevation in blood pressure).
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