This proteolytic enzyme, Protease S (formerly known as Seaprose S), is a semi-alkaline serine-proteinase produced by the fungus Aspergillus melleus. Seaprose-S demonstrates an ability to reduce painful inflammation and break up mucus. Seaprose is able to inactivate human alpha 1-proteinase inhibitor with limited proteolysis and it has mild elastinolytic capacity. Brings relief for respiratory problems such as bronchitis, pulmonary tuberculosis, pulmonary emphysema, bonchiolitis and bronchial asthma.
Seaprose is an ingredient in Japanese over-the-counter cold remedies. Seaprose has demonstrated potential against harmful bacteria like streptococcus.
These actions are useful for supporting the body against respiratory infections like bronchitis and sinusitis, both caused by bacteria and characterized by inflammation and mucus build-up.
In Studies: Seaprose may help alleviate pain, swelling and inflammation. Studies in vivo have shown that Seaprose S demonstrated potent anti-inflammatory activity, inhibiting edema, and potent bradykinin (a chemical mediator of inflammation) decomposition activity. Seaprose demonstrates an ability to reduce painful inflammation and break up mucus.1
In a study, Seaprose's effectiveness was assessed in 20 patients with chronic bronchitis. Half of the group took Seaprose while the other half took a placebo; the researchers assessed the effects by analysing each patient's bronchial mucus. Patients who took Seaprose showed significant improvements in bronchial inflammation and in the viscosity of the mucus (the liquid's rate of resistance to flow).2
In a study, Seaprose has shown anti-inflammatory activity against many different inflammatory conditions, including arthritis, oedema, pleurisy (inflammation of the lung lining), and peritonitis (inflammation of the lining of the abdomen).4
In a study, Seaprose significantly reduce the pain, oedema, cramping, and skin redness associated with inflammation of the veins. A condition called thrombophlebitis, and it is associated with blood clot formation3
1 Braga PC, Rampoldi C et al "In vitro rheological assessment of mucolytic activity induced by seaprose" Pharmacol Res 1990;22(5):611-617
2 Braga PC, Moretti M et al "Effects of seaprose on the rheology of bronchial mucus in patients with chronic bronchitis" Int J Clin Pharmacol Res 1993;13(3):179-185
3 Bracale G, Selvetella L "Clinical study of the efficacy of and tolerance to seaprose S in inflammatory venous disease" Minerva Cardioangiol 1996;44(10):515-524
4 Fossati A "Antiinflammatory effects of seaprose-S on various inflammation models" Drug Exp Clin Res 1999;25(6):263-270
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