A coenzyme in the metabolism of amino acids, glycogen, and sphingoid bases.
Helps in normal function of nervous systems. Involved in more functions than any other single welltrient
The bioactive metabolite of Vitamin B-6, Pyridoxil 5'-phosphate is a coenzyme of many enzymatic reactions. It is the active form of Vitamin B-6 which comprises three natural organic compounds, pyridoxal, pyridoxamine and pyridoxine. An essential welltrient for the utilization of proteins, fats and carbohydrate metabolism. Involved in a numerous amount of body functions. Necessary for the synthesis & breakdown of amino acids, the building blocks of protein. Pyridoxine is essential for the metabolism of protein, helps to convert glycogen into glucose, which can be used by your muscles for energy. Needed for production of red lood cells and antibodies, which fight disease. Important for metabolism of protein and proper nervous system functioning. One of the critical factors that controls sodium/potassium levels in body fluids.
Required for metabolism and brain functions, the formation of red blood cells, sodium and potassium balance, proper synthesis of RNA and DNA, immune system function and is an important nutrient in proper body organ functions. Helps with healing and immunity. Vitamin B-6 also aids in assimilation of amino acids. Helps improve the intraocular cellular metabolism of the eyes. Vitamin B6 is helpful for those who suffer from water retention. It is helpful in the necessary production of hydrochloric acid(hcl), aids in B12 absorption, combines with methionine to form cysteine, inhibits the formation of the toxic chemical homocysteine, prevention of oxalate kidney stones, and activates many enzyme activities. Helps promote a restful state by aiding in the production of the brain chemical serotonin, which is essential for restful REM sleep. Needed for normal brain function and need for the nervous system. It helps promote a restful state.
Pyridoxil 5-Phosphate is a bioactive metabolite of B-6.
History: Vitamin B6 is a water-soluble compound that was discovered in the 1930s during nutrition studies on rats. The vitamin was named pyridoxine to indicate its structural homology to pyridine. Later it was shown that vitamin B6 could exist in two other, slightly different, chemical forms, termed pyridoxal and pyridoxamine. All three forms of vitamin B6 are precursors of an activated compound known as pyridoxal 5'-phosphate (PLP), which plays a vital role as the cofactor of a large number of essential enzymes in the human body.
Enzymes dependent on PLP focus a wide variety of chemical reactions mainly involving amino acids. The reactions carried out by the PLP-dependent enzymes that act on amino acids include transfer of the amino group, decarboxylation, racemization, and beta- or gamma-elimination or replacement. Such versatility arises from the ability of PLP to covalently bind the substrate, and then to act as an electrophilic catalyst, thereby stabilizing different types of carbanionic reaction intermediates.
Overall, the Enzyme Commission (EC; http://www.chem.qmul.ac.uk/iubmb/enzyme/) has catalogued more than 140 PLP-dependent activities, corresponding to ~4% of all classified activities.
Technicals: Comprised of a group of six related compounds: pyridoxal (PL), pyridoxine (PN), pyridoxamine (PM), and their respective 5'-phosphates (PLP, PNP, and PMP). It is a coenzyme which participates in more than 60 enzymatic reactions involved in the metabolism of amino acids and essential fatty acids. Required for the body to turn histidine into histamine. It is primarily in the liver that Pyridoxal-5-phosphate (P5P) is synthesized from pyridoxine with the help of enzymes this requires Vitamin B2, zinc and magnesium for their activity.
Synergist: B-Complex, B-1, B-2, Pantothenic Acid, Vitamin C, Magnesium, Potassium. It enhances the effect of L-Ornithine. A required cofactor for the absorbtion of magnisium, protein and fatty acids.
Clinical research has established the value of B-6 supplementation in conditions including:
Autism, ADHD, and other developmental disorders
Carpal tunnel syndrome
Edema and water retention
Deficiencies Caused by: Dieters are often found to be deficient.
Signs or Symptoms of a Deficiency: A wide variety of symptoms such as skin and nervous disorders; acne, facial oiliness, seborrheic dermatitis, glossitis, cheilosis, angular stomatitis, peripheral neuropathy, fatigue. More Deficiency symptoms; depression,
poor dream recall,
cracks around mouth & eyes,
dermatitis & acne,
stillbirths from deficiency during pregnancy,
decreased vitamin c levelsv
increased sensitivity to sound,
decreased resistance to infection,
impaired wound healing,
impaired calcium utilization,
decreased absorption of copper,
decreased iron status,
decreased vitamin b 12 absorption,
carpal tunnel syndrome,
temporary limb paralysis,
numbness & tingling in the limbs,
elevated homocysteine levels,
low blood sugar,
low glucose tolerance,
In infants, convulsions.
Caution: Pregnant and lactating women should not take more than 100 mg of vitamin B6 per day.
The statements on this Web site have not been evaluated by the Food and Drug Administration (FDA). And are not intended to diagnose, treat, cure or prevent disease. The information presented is not intended to replace medical advice or treatment from your own doctor or healthcare provider. Nothing presented here is intended as a substitute for prescription medication or any other medical treatment prescribed by your doctor.